Equilibrium or not? Mathematical differences between acute & chronic virus infections

セミナー NEW WGセミナー
カトゥリン・ボシゥメンの写真 カトゥリン・ボシゥメン
日時
2022年5月25日(水)13:30 - 15:00 (JST)
講演者
会場
  • via Zoom
言語
英語
ホスト
Hidetoshi Taya

The widely acclaimed 1995/1996 papers by Ho, Perelson and others [1,2] demonstrated the important insights that come from mathematical modelling of virus infection kinetics within a person. But there are key dynamical differences between chronic and acute infections, namely whether the infection reaches or maintains some equilibrium or not. In this talk, I will introduce the equations used to describe a virus infection within a person. I will show some of the tricks used by mathematical modellers to extract important rate estimates from measurements in patients infected with chronic diseases, like HIV or Hepatitis C virus. I will explain why it is difficult to extract meaningful information from measurements in patients with an acute infection, like influenza or possibly COVID-19 [3]. I hope to hear from the audience if they have any thoughts about overcoming the issue to extract better rate information from limited data in patients with acute infections.

(This seminar is a joint seminar between Nonequilibrium working group and Biology study group)

References

  1. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M., Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection, Nature 373 (6510) 123-6 (1995), doi: 10.1038/373123a0
  2. Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD, HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time, Science (1996), doi: 10.1126/science.271.5255.1582
  3. Palmer J, Dobrovolny HM, and Beauchemin CAA, The in vivo efficacy of neuraminidase inhibitors cannot be determined from the decay rates of influenza viral titers observed in treated patients, Sci. Rep., 7:40210 (2017), doi: doi:10.1038/srep40210

このイベントは研究者向けのクローズドイベントです。一般の方はご参加頂けません。メンバーや関係者以外の方で参加ご希望の方は、フォームよりお問い合わせ下さい。講演者やホストの意向により、ご参加頂けない場合もありますので、ご了承下さい。

このイベントについて問い合わせる