日時
2023年1月5日(木)16:00 - 17:00 (JST)
講演者
  • 佐藤 勝彦 (北海道大学 電子科学研究所 准教授)
会場
  • via Zoom
言語
英語
ホスト
Hiroshi Yokota

Cellular migration is a key component of numerous biological processes, including the morphogenesis of multicellular organisms, wound healing, and cancer metastasis, where cells adhere to each other to form a cluster and collectively migrate. Although the mechanisms controlling single-cell migration are relatively well understood, those underlying multiple-cell migration still remain unclear. A key reason for this knowledge gap is the so-called many-body problem. That is, many forces—including contraction forces from actomyosin networks, hydrostatic pressure from the cytosol, frictional forces from the substrate, and forces from adjacent cells—contribute to cell cluster movement, making it challenging to model, and ultimately elucidate, the final result of these forces. In this talk, I provide a two-dimensional cell membrane model that represents cells on a substrate with polygons and expresses various mechanical forces on the cell surface, keeping these forces balanced at all times by neglecting cell inertia. The model is discrete but equivalent to a continuous model if appropriate replacement rules for cell surface segments are chosen. When cells are given a polarity, expressed by a direction-dependent surface tension reflecting the location dependence of contraction and adhesion on a cell boundary, the cell surface begins to flow from front to rear as a result of force balance. This flow produces unidirectional cell movement, not only for a single cell but also for multiple cells in a cluster, with migration speeds that coincide with analytical results from a continuous model. Further, if the direction of cell polarity is tilted with respect to the cluster center, surface flow induces cell cluster rotation. The reason why this model moves while keeping force balance on cell surface (i.e., under no net forces from outside) is because of the implicit inflow and outflow of cell surface components through the inside of the cell. I provide an analytical formula connecting cell migration speed and turnover rate of cell surface components.

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