Response to sounds in the cochlea of the inner ear
- 日時
- 2023年9月26日(火)16:00 - 17:00 (JST)
- 講演者
-
- 太田 岳 (大阪大学 大学院医学系研究科薬理学講座統合薬理学 助教)
- 会場
- via Zoom
- 言語
- 英語
- ホスト
- Shingo Gibo
We hear sounds. The acoustic wave passes through the ear canal and oscillates the ear drum. The middle ear bones conduct the mechanical input into the cochlea, the primary sensory organ of hearing. A sensory epithelium, a sheet-like tissue inside the snail-like structure, decomposes the sound frequencies into each component along the coil. The sound stimulation evokes nanometer-scale motions in the epithelium which contains hair cells. The cells expose their hair bundles to endolymph, the extracellular solution characterized by high [K+]. The epithelium vibration changes the open probability of mechanosensitive channels on the bundles and modulates the ion entering from the fluid. Inner hair cells release neurotransmitters to the auditory nerves and outer hair cells shrink and elongate their soma depending on the receptor potentials. The electromotive response amplifies the vibration of the sensory epithelium and contributes to the faint sound sensitivity and sharp frequency selectivity. With developed technique, we observed the sound-evoked vibrations in the sensory epithelium. In this seminar, I will introduce the physiological background of the cochlear physics and the recent results.
このイベントは研究者向けのクローズドイベントです。一般の方はご参加頂けません。メンバーや関係者以外の方で参加ご希望の方は、フォームよりお問い合わせ下さい。講演者やホストの意向により、ご参加頂けない場合もありますので、ご了承下さい。