Ecology and Evolution of Mammal-Microbe Interactions

A critical open question in microbiome research is identifying key host-microbial interactions that influence host fitness. While the disruption of coevolved host-microbial interactions is known to affect host fitness in simpler systems (e.g., insects and their symbionts), understanding the extent and consequences of host-microbial coevolution in more complex systems (e.g., mammals and their gut microbiota) remains a major challenge. My research has identified multiple species of gut microbes in adults and children that share a parallel evolutionary history with humans by analyzing paired human genotypes and bacterial strain genotypes. In another line of work, I applied a selection experiment demonstrating that selection and transmission of the microbiome and its metabolites can alter mouse locomotion behavior within four rounds of microbiome transfer, without any changes to the mouse genome. Finally, I will briefly outline my future plans to study the effects of disrupting evolutionary stable host-microbial associations on the phenotypes of deer mice (Peromyscus spp.) in the Madrean Sky Islands and genetically diverse human populations in Arizona.

Biosketch:
Assistant Professor at Arizona State University since 2023. MS at University of Arizona, PhD at University of California Berkeley, and Postdoc at Max Planck Institute for Biology. My group integrates evolutionary genomics, microbial ecology, and biomedical research to study host-microbial interactions using wild rodents and humans.