Modeling Membrane Morphological Change during Autophagosome Formation
- 2021年5月14日10:00 - 11:00 (JST)
- 境 祐二 (数理創造プログラム 客員研究員 / 東京大学 大学院医学系研究科 助教)
- via Zoom
Membrane-bound organelles compartmentalize eukaryotic cells and adopt various characteristic shapes such as disk-shaped, tubules, spherical vesicles, and their intermediate structures. Organellar morphology is regulated by protein and lipid compositions. Because organellar shape directly relates to organellar function, it is important to understand the mechanisms regulating organelle morphology. In autophagy, the morphologies of the isolation membrane change from disk- to cup-shaped, closed spherical double-membrane structure. Eventually the membrane engulfs the cytoplasmic materials. In this study , we investigate the dynamics of the continuous membrane morphological transition in autophagy, which is governed by the spatiotemporal regulation of curvature generators.
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- Y. Sakai, et al., iScience 23, 9, 101466, 2020