Programmed chromosome eliminations in flies

Species that break the traditional rules of genetics and inheritance offer perhaps some of the best opportunities to study fundamental biological questions. Sciarids (fungus gnats) are a species-rich family of flies with highly unorthodox chromosome inheritance. Asymmetric male meiotic divisions result in elimination of the paternal genome every generation, and maternally-controlled eliminations of chromosomes in the developing embryo determine offspring sex. I use a combination of genomics, population genetics, and cytogenetics to understand both the mechanisms and the evolution of this system. I will discuss how these approaches have allowed us to uncover some fascinating biology as well as tackle broader biological questions.