Introducing the organizational structure of iTHEMS.

  • RIKEN Center for Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS) Director: Satoshi Iso
    • Division of Fundamental Mathematical Science Director: Satoshi Iso
      • Mathematical Genomics RIKEN ECL Research Unit RIKEN ECL Research Unit Leader: Leo Speidel

        Our lab focuses on the development and application of new mathematical and statistical techniques to reveal the evolutionary forces that have shaped our DNA, from key events in a nation’s recent past to the earliest days of our species. Our methods reconstruct past migrations and mixtures, introgression with Neanderthals and other extinct hominids, changes in the molecular machinery generating DNA differences, or map the genetic adaptation that enabled survival against changing environmental exposure. We achieve this by reconstructing “genetic family trees” using genetic data sequenced from thousands of modern-day people as well as genomes sequenced from ancient human bone.

    • Division of Applied Mathematical Science Director: Tetsuo Hatsuda
      • AI for Science Team Team Director: Satoshi Iso

        This team promotes “AI for Science,” an initiative to accelerate research in natural and social sciences through cutting-edge AI research grounded in mathematical sciences, in collaboration with researchers both within and outside iTHEMS.

      • Mathematical Application Research Team Team Director: Motoko Kotani
      • Quantum Mathematical Science Team Team Director: Tetsuo Hatsuda
      • Medical Science Data-driven Mathematics Team Team Director: Eiryo Kawakami

        Our laboratory integrates artificial intelligence, systems biology, and data science to understand and predict complex human diseases. We analyze multimodal data—including molecular profiles, clinical records, imaging, and wearable sensors—to build interpretable models for precision medicine. Our research spans areas including cancer, metabolic disorders, orthopedics. By combining data-driven discovery with biomedical insight, we aim to uncover hidden mechanisms of health and disease. Collaborating across disciplines, we strive to create practical tools that support early diagnosis, patient stratification, and personalized intervention. Ultimately, we aim to develop digital twin technologies that seamlessly connect the physical and cyber realms of human health.

      • Medical Science Deep Learning Team Team Director: Jun Seita

        Our laboratory conducts research on establishing the fundamental theories necessary for applying deep learning to the field of medical science. Specifically, our main research themes include constructing deep learning frameworks that perform predictions using time series data as input, reinforcement learning as a society in which numerous deep learning agents interact, and applying these fields to quantum computing.

      • Prediction Science Research Team Team Director: Takemasa Miyoshi
      • Mathematical Social Science Team Team Director: Tetsuo Hatsuda
    • Division of Global Collaborations and Research Talent Development Director: Tsukasa Tada
      • Kyushu University Collaboration Team Team Director: Ryoko Oishi-Tomiyasu

        Our team values interdisciplinary exchange by making use of our connections with Kyushu University and the Institute of Mathematics for Industry (IMI). We are holding seminars and coding sessions to foster unexpected discoveries and opportunities for dialogue. We also engage in activities that emphasize the interface between theory and real-world applications, while maintaining a focus on deepening academic understanding.

      • RIKEN-Berkeley Center RIKENーBerkeley Center Director: Shigehiro Nagataki

        The RIKEN Berkeley Center, located at the University of California, Berkeley, operates as part of the Center for iTHEMS. The RIKEN Berkeley Center advances integrative research in fundamental physics, including quantum gravity, particle physics, nuclear physics, and the extreme universe. It plays a key role in promoting international collaboration and facilitating researcher exchange between Japan and the U.S., contributing to the global circulation of knowledge. In addition, its members regularly visit RIKEN’s sites in Japan to deepen engagement and foster vibrant interaction with researchers based in Japan.

    • Division of Social Cooperation and Outreach Director: Tomoya Nagai
    • Office of the Center Director Director: Tomoya Nagai