Origin and evolutionary history of an urban underground mosquito

Urbanization is rapidly reshaping landscapes around the world, which poses questions about whether and how quickly animals and plants can adapt. Culex pipiens form molestus, more commonly known as the "London Underground mosquito," has been held up as a benchmark for the potential speed and complexity of urban adaptation. This intraspecific lineage within Cx. pipiens, a major West Nile virus vector, is purported to have evolved human biting and a suite of other human-adaptive behaviors in the subways and cellars of northern Europe within the past 200 years. Form molestus features prominently in textbooks as well as scholarly reviews of urban adaptation. Yet, the hypothesis of in situ urban evolution has never been rigorously tested.

I will talk our recent efforts to understand the contentious origin and evolutionary history of the urban, human-biting mosquito. Our synthesis and meta-analysis of rich yet confusing literature show that its London Underground origin is unlikely (Haba and McBride 2022 Current Biology). Whole genome resequencing and population genomics of 800+ mosquitoes across ~50 countries again debunk the in situ evolution hypothesis and instead support that molestus first adapted to human environments >1000 years ago in the Mediterranean or Middle East, most likely in ancient Egypt or another early agricultural society (Haba et al. 2025 Science). I will outline implications of our results in urban evolutionary biology as well as in public health.

Speaker Bio
Yuki Haba, Ph.D., is an evolutionary biologist passionate about understanding how and why diverse behaviors evolve in nature. He is currently a Leon Levy Scholar in Neuroscience at Columbia University's Zuckerman Mind Brain Behavior Institute. He aims to take multi-desciplinary approaches, combining genomics, neuroscience, and field-based behavioral ecology to comprehensively understand the evolution of behavior. Yuki completed his PhD at Princeton, MA at Columbia, and undergraduate degree at the University of Tokyo. Personal webpage: https://yukihaba.github.io/