February 2 (Thu) at 16:00 - 17:00, 2023 (JST)
  • Prof. Kunihiko Kaneko (Professor, Niels Bohr Institute, University of Copenhagen, Denmark)
  • via Zoom
Jizhou Li

A macroscopic theory for adaptive changes of cells is presented, based on consistency between cellular growth and molecular replication, as well as robustness of fitted phenotypes against perturbations. Adaptive changes in high-dimensional phenotypes are shown to be restricted within a low-dimensional slow manifold, from which a macroscopic law for cellular states is derived, as is confirmed by adaptation experiments of bacteria under stress. The theory is extended to phenotypic evolution, leading to proportionality between phenotypic responses against genetic evolution and by environmental adaptation, which also explains the evolutionary fluctuation-response relationship previously uncovered. Relevance of statistical-physics and dynamical-systems approach is discussed.


  1. Kaneko K., Life: An Introduction to Complex Systems Biology, Springer (2006)
  2. K. Kaneko, C.Furusawa, T. Yomo, Macroscopic phenomenology for cells in steady-growth state, Phys.Rev.X, 011014 (2015)
  3. C. Furusawa, K. Kaneko, Global Relationships in Fluctuation and Response in Adaptive Evolution, J of Royal Society Interface 12, 20150482 (2015)
  4. C. Furusawa, K. Kaneko, Formation of Dominant Mode by Evolution in Biological Systems, Phys. Rev. E 97, 042410 (2018)
  5. K. Kaneko, C. Furusawa, Macroscopic Theory for Evolving Biological Systems Akin to Thermodynamics, Annual Rev. Biophys. 47, 273-290 (2018)
  6. A.Sakata and K. Kaneko, Dimensional Reduction in Evolving Spin-Glass Model: Correlation of Phenotypic Responses to Environmental and Mutational Changes, Phys. Rev. Lett. 124, 218101 (2020)
  7. Q-Y. Tang and K. Kaneko, Dynamics-evolution correspondence in protein structures, Phys. Rev. Lett. 127, 098103 (2021)

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