April 25 (Thu) at 16:00 - 17:00, 2024 (JST)
  • Rajkumar Singh Kalra (Staff Scientist, Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University (OIST))
  • via Zoom
Catherine Beauchemin

Cell ageing is an inevitable biological process. It marks declined homeostatic processes in a cell, the impact of which is reflected in the organism’s function/physiology. Ageing, thus, raises risks of disease progression in elderly people and compromises their immunity. Progression of cancer and neurodegenerative diseases and weak immune response against a pathogen(s) represent cases of ageing-related diseases. What molecular factors/signaling could be associated with disease progression or take part in governing such decisions in aging? – remained a key focus of my research so far. In my talk, I shall shed light on the part characterizing key proteins and their signalling in ageing-related diseases with an emphasis on cancer, neurodegenerative disease, and immunity. Taking advantage of wet lab and system biology studying gene networks, and genomic, proteomic, and metabolomic readouts, I investigated the molecular expression and processes impacted and compromised by ageing. I shall be discussing new knowledge from my work on the linkage of cell ageing and disease progression and therein role of key factors and facilitators I studied.

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