Theoretical analysis of High-dose/Refuge strategy for durability of pest control

When using chemicals to control pathogens or pests, a problem that always arises is that parasites develop resistance to the chemicals. In many cases, the amount of chemical used must be reduced for using the chemicals sustainably. However, if certain conditions are met, a method is known that can suppress the development of resistance in diploid organisms such as pest insects. This is the high-dose/refuge strategy (HD/R) proposed by Comins (1977). This unique method combines high doses of pesticide spraying with ‘Refuge’ that are completely pesticide-free, and is a rare example of a successful method that actually fields.
In this presentation, I will provide an overview of the HD/R strategy, a formulation that incorporates the entire life cycle of the insect, which was an issue that Comins had not yet resolved. And show the life cycle of the insect and the conditions under which the HD/R strategy is effective, based on the results of an approximation using a source-think model.