December 16 at 10:00 - 11:00, 2021 (JST)
Dr. Motomu Matsui (Research Associate, Graduate School of Science, The University of Tokyo)
via Zoom

Phylogenetic tree inference is the foundation to answer any biological questions, for example, how the living systems were established. However, the existing methods show poor performance to infer the phylogenetic tree when constructing an informative multiple sequence alignment (MSA) is difficult. In this talk, I will first review the current problems in phylogenetics, then introduce the graph splitting (GS), and edge perturbation (EP) method. The GS method rapidly reconstructs a protein superfamily-scale phylogenetic tree using a graph-based approach; evolutionary simulation showed that the GS method can accurately reconstruct phylogenetic trees when sequences substantially diverge. The EP method is the bootstrap-like method using pairwise sequence alignment (PSA) instead of MSA, which can provide reliable measurements on the estimated branches. In addition, we can rapidly and reliably reconstruct a phylogenetic tree with problematic MSA switching NJ+EP and GS+EP methods, because the EP method can be applied to the NJ method. These methods not only improve the accuracy of phylogenetic tree inference, but they also could open the door for revisiting phylogenetics.

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