Evaluation of origin of driving force for loop formation in a chromatin fiber

During cell division, chromatin fiber is condensed into the rod-like shape which is called chromosome. The rod-like shape of the chromosome is constructed by consecutive chromatin loop structures which are formed by the protein complex named condensin. In this talk, by calculating the driving force for the loop formation, we discuss the mechanism of loop formation which is the one of the controversial issues on chromosome condensation. The driving force is evaluated based on the free energy of the chromatin loop formation by constructing the polymer model. Based on the free energy, the loop growth length in the unit time is also evaluated. These evaluations also lead to the time evolution of the loop length and the mechanism of the loop formation.