Volume 313
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Press Release
Decoding Protein Condensation - Predicting Condensation of Proteins from Amino Acid Sequences -
2024-07-24
The research team of Kyosuke Adachi (Research Scientist, iTHEMS / Research Scientist, Nonequilibrium Physics of Living Matter RIKEN Hakubi Research Team, RIKEN BDR) and Kyogo Kawaguchi (Team Leader, Nonequilibrium Physics of Living Matter RIKEN Hakubi Research Team, RIKEN BDR / Associate Professor, Institute for Physics of Intelligence, The University of Tokyo) has proposed a theory that predicts the condensation of protein molecules and demixing of condensates based on amino acid sequences.
This research is expected to contribute to elucidating the mechanisms for the formation of membraneless organelles in cells and, in the future, to develop into a theory that predicts the effect of mutations in proteins sequences on cellular functions.
For more details, please refer to the related link.
Reference
- Kyosuke Adachi and Kyogo Kawaguchi, Predicting Heteropolymer Interactions: Demixing and Hypermixing of Disordered Protein Sequences, Phys. Rev. X 14, 031011 (2024), doi: 10.1103/PhysRevX.14.031011
Hot Topic
SLMath Summer Graduate School "h-principle" on July 1, 2024
2024-07-26
The SLMath Summer Graduate School "h-principle" Sendai 2024 was held from July 1 to July 12, 2024 at TOKYO ELECTRON House of Creativity (Chi no Yakata) in Katahira Campus of Tohoku University. This two weeks lomg summer graduate school was organized by Simons Laufer Mathematical Sciences Institute (SLMath) and RIKEN iTHEMS, and coorganized by Mathematical Science Center for Co-creative Society (MathCCS) and Tohoku Forum for Creativity (TFC) of Tohoku University. There were 18 graduate students from the supporting institutions of SLMath and 12 graduate students from Japanese universities. There were four courses consisting of five 90 mintes lectures given by Emmy Murphy (Toront University), Dominik Inauen (Leipzig University) and Takashi Tsuboi (RIKEN iTHEMS / Tohoku University). The titles of lectures were "h-principles in smooth topology" by Emmy Murphy and "Riemannian geometry and applications to fluid dynamics" by Dominik Inauen in the first week, and "Contact and symplectic flexibility" by Emmy Murphy and "Foliation theory and diffeomorphism groups" by Takashi Tsuboi in the second week. We took video of the lectures and it can be seen later from the website of SLMath. There were 4 teaching assistants, Toru Yoshiyasu (Kyoto University of Education), Noboru Ogawa (Tokai University), Masato Ogawa (Tohoku University) and Sonia Mahmoudi (SUURI-COOL Sendai, Tohoku University) who took care of the 30 graduate students. Some details can be seen at SLMath website. The staffs of RIKEN iTHEMS, SUURI-COOL Sendai and MathCCS supported this summer graduate school for all the time, and all the participants are realy grateful for their help. TOKYO ELECTRON House of Creativity is really a nice place for the discussions in front of blackboards, and the house was filled with the discussions among the participants for 9:00 - 17:30 and some of the discussions continued in the meeting room in the hotel. The welcome party and the farewell party of Summer Graduate School were held jointy with the participants of G-RIPS Sendai 2024 which went on at MathCCS and which iTHEMS is cohosting.
Reported by Takashi Tsuboi
SLMath Summer Graduate School "h-principle"
July 1 (Mon) - 12 (Fri), 2024
Research News
The annual S&T poster for everyone “One S&T poster for Every Household” produced by the MEXT celebrates its 20th anniversary with a special issue
2024-07-24
To commemorate the 20th anniversary this year of the annual S&T poster for everyone “One S&T poster for Every Household” published by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) during Science and Technology Week in April every year, a PDF version of the Science Window ‘One S&T poster for Every Household 20th Anniversary Special Issue’ was published in June.
You can read all pages from the first one, ‘Periodic Table of Elements’, to the 20th, ‘Mathematics’, as well as columns on three themes: the Periodic Table of Elements, the Human Genome Map and Mathematics. The printed booklet is expected to be completed in autumn.
Upcoming Events
Seminar
Quantum Gravity Gatherings
Lectures on Black Holes, Holography and Quantum Gravity
July 29 (Mon) - August 1 (Thu), 2024
Yasunori Nomura (Director, Berkeley Center for Theoretical Physics, University of California, Berkeley, USA)
The information problem of black holes has evolved modern physics and led to the holographic principle, considered the fundamental principle of quantum gravity. Through a series of four lectures (blackboard style), including naive questions from the audience and lively discussions, I will introduce these fundamental ideas as well as the current state of the art and problems in cutting-edge research.
Lecture 1: July 29 (Mon) 13:30~15:00
(Lecture 2: July 30 (Tue) 13:30~15:00 was canceled)
Lecture 3: July 31 (Wed) 13:30~15:00
Lecture 4: Aug 1 (Thu) 13:30~15:00 (+ A possible lecture )
Venue: Hybrid Format (3F #359 and Zoom), Seminar Room #359, 3F Main Research Building, RIKEN
Event Official Language: English
Special Lecture
RIKEN iTHEMS & AIPmath Special Lecture: Contact geometry in 3-dimensional space and higher
July 29 (Mon) at 15:30 - 16:30, 2024
Emmy Murphy (Professor, Princeton University, USA)
In mathematics, contact geometry is a type of geometry describing a variety of dynamical systems. They are the phase spaces of systems arising in geometric optics, semi-classical quantum systems, classical dynamics, and control theory. On the mathematical side, contact geometry relates to a variety of other geometric structures, such as Kahler geometry, smooth topology, and foliation theory. It can be especially interesting to look at contact geometry in 3-dimensional space, because we can explicitly visualize the spaces. Additionally, by connecting contact geometry with our understanding of 3-D topology, mathematicians have the ability to understand the large-scale structure of these spaces like never before.
The talk will introduce the basics of contact geometry and its applications. We'll particularly focus on the 3-dimensional case, while also mentioning some of the unique properties of higher-dimensional spaces which are recently being explored.
Registration required: Register before Wednesday, July 24, 15:00.
Venue: RIKEN Tokyo Liaison Office (Nihonbashi) / via Zoom
Event Official Language: English
Seminar
iTHEMS Theoretical Physics Seminar
Algebraic curves and parametric resurgence
July 29 (Mon) at 16:30 - 17:45, 2024
Samuel Crew (Postdoctoral Fellow, Imperial College London, UK)
In this talk I will discuss recent work together with Ines Aniceto (Southampton) on algebraic examples of parametric resurgence. We discuss a simple example to elucidate the so-called higher order Stokes phenomena and discuss how a Borel inner-outer matching procedure allows us to view parametric resurgence as a series of non-parametric resurgence problems.
Venue: Hybrid Format (3F #359 and Zoom), Main Research Building, RIKEN
Event Official Language: English
Seminar
iTHEMS Biology Seminar
Social behavior and social engineering in bacteria
August 1 (Thu) at 16:00 - 17:00, 2024
Ashleigh Griffin (Professor, Department of Biology, University of Oxford, UK)
This year is the 60th anniversary of WD Hamilton’s seminal paper in which he outlined his theory of inclusive fitness and showed how it could be used to understand altruism in the social insects. In this talk, I will describe efforts made to use his theory to understand social behavior in bacteria. And I’ll go on to explore the potential of using these insights to tackle problems of antibiotic resistance in infections.
Venue: Seminar Room #359, 3F Main Research Building, RIKEN / via Zoom
Event Official Language: English
Others
What will Happen to iTHEMS⊗Masason Foundation Members?
August 2 (Fri) at 13:30 - 17:30, 2024
Venue: Seminar Room #359, 3F Main Research Building, RIKEN
Event Official Language: English
Workshop
NCTS-iTHEMS Joint Workshop on Matters to Spacetime: Symmetries and Geometry
August 26 (Mon) - 29 (Thu), 2024
The National Center for Theoretical Sciences (NCTS) and the Interdisciplinary Theoretical and Mathematical Sciences Program (iTHEMS) at RIKEN have long maintained a collaborative relationship, even before the Memorandum of Understanding was signed in December, 2022. This partnership has successfully facilitated joint activities in high energy physics over recent years. As the impact of the COVID-19 pandemic wanes, we are excited to announce the inaugural joint workshops focusing on condensed matter physics and (quantum) gravity. These workshops are designed to foster international collaborations and stimulate interdisciplinary research.
We are pleased to invite you to the 2024 NCTS-iTHEMS Workshop on Matters to Spacetime: Symmetries and Geometry, to be held from August 26 (Monday) to August 29 (Thursday), at the National Center for Theoretical Sciences, located on the campus of National Taiwan University (NTU) in Taipei, Taiwan. This workshop will feature presentations on the latest research findings, foster discussions to spark new ideas, and provide opportunities for initiating collaborative projects. While we strongly encourage in-person attendance to maximize engagement and interaction, an online platform will also be available to accommodate participants who are unable to attend physically.
Venue: NCTS Physics Lecture Hall, 4th Floor, Cosmology Hall, National Taiwan University
Event Official Language: English
Workshop
RIKEN - LBNL Workshop on Quantum Information Science
September 3 (Tue) - 6 (Fri), 2024
This international workshop will bring together researchers worldwide to discuss and collaborate on the latest developments in quantum technologies and quantum computing. Other focus areas will be algorithms, hybrid classical - quantum computing, error mitigation, and applications in physics and chemistry. With an emphasis to galvanize the participants into future collaborations, in addition to presentations on recent trends, the workshop will dedicate time in the afternoons for facilitated brainstorming and planning sessions.
Venue: Lawrence Berkeley National Laboratory (Berkeley, California)
Event Official Language: English
Paper of the Week
Week 4, July 2024
2024-07-25
Title: Restricted Boltzmann Machines Propagators for Auxiliary Field Diffusion Monte Carlo
Author: Jordan M. R. Fox, Alessandro Lovato, Alessandro Roggero, Ermal Rrapaj
arXiv: http://arxiv.org/abs/2407.14632v1
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