In iTHEMS biology seminar on April 14th, I introductory talked about the coarse-grained molecular dynamics simulation by using Langevin equation which is the equation of motion including the interaction, the friction and the random force. First, I mentioned the chromosome formation dynamics as an example of the application range of the simulation. Next, I explained the Langevin equation and its intuitive picture. Then, I showed the discretized Langevin equation which keeps the stochastic properties of the random force term. Finally, I showed some examples of Langevin simulation. Many questions and discussions arose from the audience. Thank you very much!