iTHEMS Colloquium was held on April 23rd, inviting Dr. Kazuhiro Sakurada, Deputy Program Director of RIKEN Medical Sciences Innovation Hub Program, also at Sony CSL, and Dr. Jun Seita, Unit Leader of AI based Healthcare and Medical Data Analysis Standardization Unit, RIKEN Medical Sciences Innovation Hub Program as the lecturers. Dr. Sakurada gave the lecture first, entitled "The Description of biological phenomena as open system." There, he explained his approach to describe the life-course changes of individual people by applying the discretization model and Markov chain model. Then followed Dr. Seita’s lecture, which is entitled "Every Biological Variable has a Different Dynamic-range." He introduced an open platform for objective gene expression profiling named Gene Expression Commons. Their lectures exhibited the power of the interdisciplinary research in the most perspicuous way.