The left-right (LR) asymmetric morphology of organs is essential for the development and maintenance of their functions in various species. In recent years, it has become clear that the LR asymmetry of organs originates from cell chirality, the LR asymmetric nature at the cellular level [1]. However, it is unclear how the cell chirality generates the LR asymmetry at the multicellular level. Here we show a mechanism of LR asymmetry formation at the multicellular level based on cell chirality. We previously found that Caco-2 cells, a typical cultured epithelial cell line derived from human colon cancer, exhibit stereotypical and directional cell chirality; when Caco-2 cells are cultured as single cells, their nuclei and cytoplasm rotate in the clockwise direction at a rate of 50°/h [2]. Interestingly, when Caco-2 forms multicellular colonies, the colonies also undergo a collective clockwise rotation at 10º/h. We revealed that the actomyosin cytoskeleton is essential for the formation of the collective rotation [2]. We also found that Caco-2 cells formed lamellipodia and focal adhesions LR asymmetrically during the collective colony rotation, which may be responsible for the chiral collective motion. Interestingly, the disruption of microtubules reversed the direction of collective rotation. The LR asymmetric formation of lamellipodia and focal adhesions was also reversed by inhibition of microtubule polymerization. We will discuss the possible mechanism and the mathematical model where cell chirality induces multicellular chiral rotation depending on microtubules.

This is an introductory course to the exact WKB analysis. Firstly we review some basic facts concerning formal power series and WKB solutions. Secondly we give an overview of the connection formulas for WKB solutions to ordinary differential equations of second order with a large parameter. Next, after recalling some classical theory for the Airy equation and the Gauss hypergeometric differential equation, we show how the exact WKB analysis is used for these equations and what are obtained. One of the main results to be presented in this course is the relation the between the classical hypergeometric function and the Borel resummed WKB solutions to the hypergeometric differential equation with a large parameter. Some applications and recent topics are also given.

[Schedule (Tentative)]
Day 1
10:00 - 11:30 Lecture 1
14:00 - 16:00 Lecture 2

Day 2
10:00 - 11:30 Lecture 3
14:00 - 16:00 Lecture 4

Day 3
10:00 - 11:30 Lecture 5
14:00 - 16:00 Lecture 6

Day 4
10:00 - 11:30 Lecture 7
14:00 - 16:00 Lecture 8

The density functional theory (DFT) is one of the powerful methods to solve quantum many-body problems, which, in principle, gives the exact energy and density of the ground state. The accuracy of DFT is, in practice, determined by the accuracy of an energy density functional (EDF) since the exact EDF is still unknown. Currently, DFT has been used in many communities, including nuclear physics, quantum chemistry, and condensed matter physics, while the fundamental study of DFT, such as the first principle derivations of an accurate EDF and methods to calculate many observables from obtained densities and excited states. However, there has been little opportunity to have interdisciplinary communication.

On December 2022, we had the first workshop on this series (DFT2022) at Yukawa Institute for Theoretical Physics, Kyoto University, and several interdisiplinary discussions and collaborationd were started. To share such progresses and extend collaborations, we organize the second workshop. In this workshop, the current status and issues of each discipline will be shared towards solving these problems by meeting together among researchers in mathematics, nuclear physics, quantum chemistry, and condensed matter physics.

This workshop mainly comprises lectures/seminars on cutting-edge topics and discussion, while a half-day session composed of contributed talks is also planned.

This workshop is partially supported by iTHEMS-phys Study Group. This workshop is a part of the RIKEN Symposium Series.

The detailed information can be found in the workshop website.

Particle cosmology is a discipline seeking a fundamental understanding of the Universe based on particle physics. Five mysteries drive our research today: cosmic inflation, baryon asymmetry, neutrino properties, dark matter, and dark energy.
Resolving any of the five mysteries will revolutionize our picture of the Universe. Numerous interesting theoretical hypotheses have been proposed to this end. Many require new scalar quantum fields, such as inflatons, axions, supersymmetric particles, etc. They are, in a sense, an attempt to expand the role of the vacuum. Since we have not found such spin-zero fields yet, we shall invent new eyes to make an experimental or observational breakthrough.
The International Center for Quantum-field Measurement Systems for Studies of the Universe and Particles (QUP) was established in December 2021 at KEK under the WPI program of MEXT and JSPS. With its tagline of "bring new eyes to humanity," one of the primary missions of QUP is inventing and developing such new eyes for particle cosmology. In this seminar, after briefly introducing QUP, I focus on research topics I have contributed, including the LiteBIRD satellite to study inflatons and light scalar quantum field searches with novel methods using quantum sensing techniques.

Silicon is the second most common element in the Earth’s crust. Some families of higher plants evolved mechanisms for soluble silica to be carried by xylem from groundwater and deposited as plant opal in or around plant cells as phytoliths thought to play a role in the structural support and defense against herbivores. While known since the early 19th century, phytoliths remain an intriguing class of microfossils whose formation and role in plants and their preservation in soils and sediments are a subject for a lot of active research. I outline some emerging themes in phytolith analysis including phytoliths’ role in global biogeochemical cycles, plant-herbivore interactions, and their tracing of evolution of cultural plants, especially cereals such as rice (Oryza), wild rice (Zizania), maize (Zea), wheat (Triticum) and millet (Panicum), all relevant to global archaeology. Some emerging research on phytoliths connects their changes in shapes to plant taxonomy of some families such as grasses and opens up avenues for further investigation of their active construction in the cells of some taxa by yet undiscovered genetically mediated mechanisms. New image analysis techniques and some advanced microscopy methods will allow us to further the field of phytolith study using deep machine learning algorithms and true 3D analysis of their shapes, something where contribution from other branches of science are most welcome.