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iTHEMS Weekly News Letter

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iTHEMS Coffee Meeting is held on every Friday

2018-08-28

iTHEMS Coffee Meeting is held on every Friday from 12:30- at our common room. From this fiscal year, we have changed the style of the short talk at the coffee meeting. The speaker will give a 15 min. talk only using blackboard without taking questions.
The talk could be a scientific problem that the speaker is facing and wants to ask advise, an interdisciplinary scientific proposal that the speaker wants to form a collaboration, an elementary introduction to a particular topic or notion, etc.

So far, this new attempt is working very well. For example, the speaker last week (Aug.24) was Gen Kurosawa who gave a talk “On the unsolved mystery of biological clock”. He posed unsolved questions on biological clock which induced lots of questions and discussions by the iTHEMS members after his talk.

As usual, we have nice cookies and candies brought from all over the world by the iTHEMS members and coffee/tea/soft-drinks prepared by iTHEMS assistants. Thanks all for supporting the coffee meeting!

Upcoming Events

Colloquium

iTHEMS Colloquium

Economic Networks: a Physicist's View

October 3 at 15:00 - 16:30, 2018

Prof. Hideaki Aoyama (Senior Visiting Scientist, iTHEMS)

Economic phenomena occur on networks formed by agents, such as firms and financial institutions. In order to understand the dynamic nature of economy, we need to understand structures of those networks and interactions between economic agents on it. In this talk, I will review several important research results on this theme, most of which uses Japanese rich, actual (not simulated) network data, including trade (production) network of about one million firms. Community structures, simulation of effect of natural disasters, new methodology required for such inquiry are some of the topics to be covered.

Venue: Large Meeting Room, 2F Welfare and Conference Building (Cafeteria), RIKEN

Broadcast: R511, Computational Science Research Building, R-CCS, Kobe Campus, RIKEN / SUURI-COOL (Kyoto), #204-205, 2F Maskawa Building for Education and Research, North Campus, Kyoto University / SUURI-COOL (Sendai), #303, 3F AIMR Main Building, Advanced Institute for Materials Research (AIMR), Tohoku University

Event Official Language: English

Workshop

Supported by iTHEMS

Workshop on Recent Developments of Chiral Matter and Topology

December 6 - 9, 2018

The aim of this workshop is to gather researchers of high-energy and condensed-matter physics working on chiral Matter and Topology, to exchange ideas and establish collaborations to tackle unsolved issues and carry out future extensions. The workshop expects to welcome 40-60 participants who are interested in the aforementioned topics.

Organizers:
Tomoki Ozawa, Tetsuo Hatsuda (RIKEN iTHEMS)
Di-Lun Yang (RIKEN Nishina Center; YITP, Kyoto)
Chang-Tse Hsieh (Kavli IPMU / ISSP, the Univ. of Tokyo)
Jiunn-Wei Chen, Guang-Yu Guo (National Taiwan Univ.)
Hsiang-Nan Li (Academia Sinica)

Venue: National Taiwan University, Taipei, Taiwan

Event Official Language: English

Paper of the Week

Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock thumbnail

Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock

2018-08-28

Thanks to the accumulation of molecular knowledges about biological clock, we can predict a missing link “X” in the system by using a realistic simulator. Meal-time is known to influence our sleep-wake timing. But the mechanism has been unknown. This time, the group of Dr. Okamura at Kyoto University discovered a new enzyme (named, Ck1δ2) that possibly links between our metabolic system and biological clock. Based on the experimental results by Dr. Okamura, two iTHEMS members (Gibo and Kurosawa) predicted the specific biochemical process, activated by the new enzyme. The prediction was conducted by using a 190 variables model with all genes and proteins. Fortunately, the prediction was confirmed experimentally. The point for the prediction was the activation of the new enzyme “slowed” the biological clock in the experiment while the activation of most enzymes “accelerate” the clock in the simulator. Now, the mechanism is studied by using a simpler model. Then, a possible scenario is that amino-acids in our food influence our sleep-wake timing via the new enzyme.

Reference:
Jean-Michel Fustin, Rika Kojima, Kakeru Itoh, Hsin-Yi Chang, Ye Shiqi, Bowen Zhuang, Asami Oji, Shingo Gibo, Rajesh Narasimamurthy, David Virshup, Gen Kurosawa, Masao Doi, Ichiro Manabe, Yasushi Ishihama, Masahito Ikawa, Hitoshi Okamura
"Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock"
Proc. Natl. Acad. Sci. USA 115, 5980-5985 (2018)
doi: 10.1073/pnas.1721371115

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