The ERBB family of receptors, consisting of ERBB1, ERBB2, ERBB3, and ERBB4, is a group of receptors that receive external signaling molecules. When the ERBB receptors receive signaling molecules, they bind to one another and induce phosphorylation reactions, leading to macroscopic responses such as cell proliferation and differentiation. However, it is difficult to measure the details of the binding and phosphorylation reactions of the ERBBs, and it has not been known how the various responses to signals are produced.

In this study, we conducted experimental measurements using cells with various compositions of ERBBs and multiple signaling molecules and constructed a mathematical model, which incorporates all possible reactions of ERBBs. By applying the mathematical model, we succeed in explaining and predicting the experimental results on phosphorylation responses. Furthermore, we identified the reactions that play an essential role in the diversity of the phosphorylation responses. Our findings may allow us to control cell responses such as proliferation and differentiation in the future.

For more details, please see the press release article from Kyoto University at related links.

Tomohiro Tanogami from Kyoto University gave a talk titled "A simple XY model for cascade transfer." Cascade transfer is a ubiquitous phenomenon that appears in various physical systems. During a cascade transfer an inviscid conserved quantity such as energy is transferred conservatively from large/small to small/large scales, which results in a universal scaling law in the spectrum (e.g., Kolmogorov energy spectrum). In the talk, Tomohiro proposed a simple XY model which shows inverse energy cascade with a non-Kolmogorov energy spectrum and pointed out that the model may characterize a novel "universality class" of cascade transfer. Tomohiro also explained possible relations between his model and, e.g., spin and atmospheric turbulences. About 20 physicists have joined the seminar and enjoyed discussions from various viewpoints.

Reported by Hidetoshi Taya

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