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iTHEMS Weekly News Letter

Upcoming Event

Workshop

Supported by iTHEMS

Workshop on Recent Developments of Chiral Matter and Topology

December 6 - 9, 2018

The aim of this workshop is to gather researchers of high-energy and condensed-matter physics working on chiral Matter and Topology, to exchange ideas and establish collaborations to tackle unsolved issues and carry out future extensions. The workshop expects to welcome 40-60 participants who are interested in the aforementioned topics.

Organizers:
Tomoki Ozawa, Tetsuo Hatsuda (RIKEN iTHEMS)
Di-Lun Yang (RIKEN Nishina Center; YITP, Kyoto)
Chang-Tse Hsieh (Kavli IPMU / ISSP, the Univ. of Tokyo)
Jiunn-Wei Chen, Guang-Yu Guo (National Taiwan Univ.)
Hsiang-Nan Li (Academia Sinica)

Venue: National Taiwan University, Taipei, Taiwan

Event Official Language: English

Paper of the Week

Structural Bifurcation Analysis in Chemical Reaction Networks thumbnail
Dr. Takashi Okada thumbnail

Structural Bifurcation Analysis in Chemical Reaction Networks

2018-07-30

In living cells, large numbers of chemical reactions form complicated networks (e.g. metabolic networks). It is considered that dynamics arising from such networks are the origin of biological functions. In this study, we developed a theoretical method to analyze bifurcation properties, i.e. properties of structural changes of steady-state solutions, from topology of reaction networks. Such a topological approach is advantageous because reaction kinetics is not well known in detail. Specifically, we showed that a reaction network can be decomposed into subnetworks based on a certain topological criteria, and showed that any bifurcation point is associated with a particular subnetwork ((3) in the figure). Further, we identified the parameters inducing bifurcations ((4) in the figure) and chemical concentrations exhibiting bifurcating behaviors ((5) in the figure). Our method is particularly useful to study large networks, since it allows us network decomposition. Biologically, bifurcation properties are related with plasticity of living systems, i.e. qualitative changes of physiological states induced by environmental conditions or gene-expressions. Our result suggests that biological plasticity arises from network topology.

Reference:
Takashi Okada, Je-Chiang Tsai, Atsushi Mochizuki
"Structural Bifurcation Analysis in Chemical Reaction Networks"
Phys. Rev. E 98, 012417 (2018)
doi: 10.1103/PhysRevE.98.012417
arXiv: 1711.00250

Person of the Week

Dr. Jeffrey Fawcett thumbnail

Self-introduction: Jeffrey Fawcett

2018-07-30

My name is Jeffrey Fawcett and I've been working at iTHEMS since March 2018. My main interest is Genome Evolution, and I work on or have worked on a broad range of topics related to genomics, evolution, genetics, bioinformatics, and systems biology.

I am a Biologist and have always been working in an environment surrounded by Biologists. So joining iTHEMS and being surrounded by so many physicists, mathematicians, formulas, blackboards, and blackholes is quite a transition for me. Yet, it is very stimulating and challenging, and I am so far enjoying this unique opportunity where I get to work alongside people with totally different backgrounds and hear about so many different topics that I would never have the chance to in a normal research environment.

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