How does the brain compute the value of odors and trigger adaptive behavior?

The world is filled with numerous odors that are impossible to experience all in our lifetime. Perhaps to cope with this situation, the brain is equipped with an ability to recognize whether an odor is attractive or aversive even from the first encounter and guide adaptive behavior. However, how information about the innate value of odors (attractiveness/aversiveness) is computed and transformed into appropriate behavioral outputs in the brain remains poorly understood. We are addressing this question in the olfactory circuit of fruit flies by combining behavioral analysis in virtual reality, comprehensive neuronal activity imaging, neuronal connectivity analysis, and computational modeling. In this talk, I will present our latest efforts to decipher how odor value is computed and how this information is transformed into motor-related signals in a tiny brain.