Homo lupo lupus est: Man is a wolf to wolves.

The gray wolf (Canis lupus) is one of the most emblematic wild species in human history: revered as a symbol of strength and wildness, although unforgivably persecuted as a competitor and pest. Across Europe and much of Eurasia, wolves would still dominate as apex predators... were it not for millennia of human pressure. Today, their evolutionary trajectory is shaped not only by climate fluctuations and habitat loss, but also by a uniquely flexible species boundary. Due to their unique karyotype, canids can admix freely with other related species, a capacity that both threatens the genetic integrity of wild canids like wolves and enriches our understanding of hybridization as a driver of adaptation. In this talk, we will explore recent studies on wolf demography under human pressure and climatic change, with particular attention to admixture with domestic dogs and the consequences for their survival in increasingly anthropized environments. Finally, we will observe how the wolf's distinctive genomic architecture makes it a powerful model for testing population genetics theoretical frameworks and for applying state-of-the-art computational tools, offering new insights into the understanding of evolution as a force for change.